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The papers below show that ingested DNA is not only circulated through the animal body but may be associated with nucleus and chromosomes.

The first paper "The fate of forage DNA in farm animals" by Einspanier et al (2001), studies ingestion of maize DNA and of GM maize DNA, while the second is an earlier study "On the fate of foreign DNA in mice" by Shubbert et al (1998) that showed that ingested DNA from a bacterial virus or from a plasmid transgene is incorporated in chromosomes and is passed from mother to fetus.

Eukaryote DNA has relatively low frequencies of the dinuleotide motif Cp G and that motif is methylated and plays a role in gene regulation while bacteria and their viruses have a high frequency of the Cp G motif that is usually unmethylated.

Apparently the Cp G motif in DNA molecules and oligonucleotides provides a signal that the immune system recognizes and initiates a primary sequence of reactions leading to activation of the immune system leading to inflammation (Manders and Thomas 2000 and Gurunathan et al 2000).

Studies of the type described above should be repeated and extended.

The authors of the study ask "is maternally ingested foreign DNA a potential mutagen for developing fetus?

" If food DNA sequences are randomly incorporated into coding sequences including introns, exons or promoters they will certainly act as mutagens.

Professor Cummins concludes: "The available evidence is sufficient to support a moratorium on the massive intake of GM crops by human populations until the genetic consequences are resolved in the laboratory." Toxicology Symposium, University of Guelph March 3, 2001 Dr.

Joe Cummins, Emeritus Professor of Genetics, University of Western Ontario, Canada In evaluating the safety of genetically modified (GM) food crops it has previously been assumed that food is completely digested and the genes of the food organisms are not circulated to the cells of the predator.

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Such genes include Bt and most herbicide tolerance genes.